91小视频在线观看-91小视频在线观看-91小视频-91小视频-欧美成人免费视频-欧美成人免费电影

食品伙伴網服務號
 
 
當前位置: 首頁 » 專業英語 » 專業知識 » 正文

組合化學 Combinatorial Chemistry -生物名詞

放大字體  縮小字體 發布日期:2005-05-13

 
運用一小組化學構建基因,以多種方式結合,用標準化學方法建立大的與醫藥相關的化合物的文庫,以用于新藥的篩選。組合化學與大規模篩選相結合用于識別與治療用靶蛋白結合的化合物即潛在新藥。最初的新的結合物稱為"標的",標的然后被優化為"先導物"并最終發展成為真正的藥物。組合化學策略依賴于欲構建文庫的大小、和多樣性,試劑的有效性和成本和化學合成的類型。總體而言,有兩種形式的組合文庫合成,"液相"合成和"固相"合成,對后者來說,化學反應是與附在支持物(如:玻珠和柱子)上的一種或多種試劑發生的。這兩種文庫合成方法都有各自的優、缺點;液相合成允許很多化學反應進行;然而所形成的文庫必然是液相混合物,必須能夠從組合混合物中區別單個化合物。固相合成的優點是單個化合物在合成中是在空間上分開的;然而必須發展新的化學反應應用于固相合成。


The use of a small set of chemical building blocks, combined together in multiple ways, using standard chemistries, to create large libraries of medicinally relevant compounds that may be screened for potential new drugs. Combinatorial chemistry is used in tandem with high-throughput screening to identify compounds that bind to a therapeutic target protein and are thus potential new drugs. Initial new binders are called
hits; hits can then be optimized into leads for further development into bona fide drugs. Combinatorial chemistry strategies depend on the size and diversity of the library to be designed, the availability and cost of the reagents (building blocks), and the type of chemical syntheses being attempted. In general, two forms of combinatorial library synthesis exist, liquid-phase synthesis and solid-phase synthesis; in the latter the chemistries are performed with one or more of the reagents attached to an inert solid support such as a bead or column. Each of the two methods of library synthesis has its own advantages and disadvantages; Liquid-phase synthesis allows many more standard chemistries to be performed (most chemical synthesis steps have been developed for individual compound synthesis in the liquid phase); however, the resultant library is necessarily a mixture of compounds within the liquid, and deconvolution strategies must be applied to identify individual compounds from the combinatorial mixture. Solid-phase synthesis has the advantage that individual compounds are spatially separated during synthesis; however, novel chemistries must be developed in order to be useable in the solid phase.

更多翻譯詳細信息請點擊:http://www.trans1.cn
 
[ 網刊訂閱 ]  [ 專業英語搜索 ]  [ ]  [ 告訴好友 ]  [ 打印本文 ]  [ 關閉窗口 ] [ 返回頂部 ]
分享:

 

 
推薦圖文
推薦專業英語
點擊排行
 
 
Processed in 0.127 second(s), 18 queries, Memory 0.91 M
主站蜘蛛池模板: 午夜影院免费入口 | 国产美女亚洲精品久久久综合 | 在线观看一级毛片 | 国产乱码精品一区二区三 | 爱插综合网 | 韩国男女无遮挡高清性视频 | 日韩三级在线观看视频 | 国产女在线 | 色婷婷亚洲十月十月色天 | 国产精品乱码高清在线观看 | 网站在线观看视频 | 激情婷婷综合久久久久 | 亚洲一区在线免费观看 | 欧美成人综合在线 | 欧美特黄特色aaa大片免费看 | 色01视频| 天天草天天操 | 亚洲午夜日韩高清一区 | 欧美亚洲综合图区在线 | 成在线人永久免费播放视频 | 天天综合天天添夜夜添狠狠添 | 成人性欧美丨区二区三区 | 三级黄网| 亚洲精品卡1卡二卡3卡四卡 | 2021久久天天躁狠狠躁夜夜 | 亚洲qingse中文久久网 | 91大神在线免费观看 | 午夜三级成人三级 | 噜噜噜色网 | 五月激情啪啪网 | 色综合天天操 | 在线色资源 | 亚欧毛片基地国产毛片基地 | 最新地址四虎www4hutv | 国产一级aa大片毛片 | 日本三级日本三级人妇三级四 | 天天视频入口 | 日本a级片视频 | 天天操天天干天天插 | 2021久久精品免费观看 | 黄色毛片免费进入 |