為什么在神經元退變疾病(neurodegenerative disease)中一些神經元被選擇性地指向死亡?最新的一篇文章結合了果蠅和小鼠的遺傳學,揭示了蒲肯野細胞(Purkinje cell)在脊髓小腦性共濟失調-1(spinocerebellar ataxia-1)中易受攻擊的秘密。
(Figure 1. Tsuda et al. demonstrate homologous pathways that mediate ataxin-1–induced neurodegeneration in mouse and Drosophila models of SCA-1.)